Fluid Overload Management
Powered by Your Skin
Fluid Overload
Management Powered
by Your Skin
Powered by Your Skin
Management Powered
by Your Skin
Non-invasive, Kidney Independent Solution
Aquapass technology enables excess fluid removal through the skin,
independent of kidney function – a first-of-its-kind approach
with two FDA Breakthrough Device Designations
A Growing Crisis in Fluid Overload
Over 17 million patients suffer from fluid overload due to heart or kidney failure, leading
to more than 3 million annual admissions, high readmission rates, and worsening outcomes
to more than 3 million annual admissions, high readmission rates, and worsening outcomes
11.5M
Chronic Kidney
Disease Patients
Disease Patients
6.2M
Heart Failure
Patients
Patients
850K
End-Stage Kidney
Disease Patients
Disease Patients
Current therapies for fluid overload target the intravascular space, are ineffective
and carry a significant risk of complications.
and carry a significant risk of complications.
Transforming the Skin into a Natural
Fluid Removal System
A patented technology that activates the eccrine (sweat) glands to remove excess fluid independent of kidney function. The system draws fluid directly from where it accumulates. The extravascular space.
Effective
High Volume Fluid Removal, >250 ml/hr
Controlled Decongestion
Easy to Use
Suited for Various Care Settings
Comfortable and Intuitive Design
Safe
Noninvasive and Kidney Independent
Stable Hemodynamics
Unlocking the Skin’s Potential
Like the kidneys, sweat glands clear fluid, electrolytes, and waste.
Kidney Nephron
Filter Water and
Electrolytes
Electrolytes
Na+, Cl-, K+, Mg2+,
Ca2+
Ca2+
Urea and Uric Acid
↑Na+ Excretion at High Filtration Rate
Eccrine Gland
Excrete Water and
Electrolytes
Electrolytes
Na+, Cl-, K+, Mg2+,
Ca2+
Ca2+
Urea, Uric Acid
and Heavy Metals
and Heavy Metals
↑Na+ Excretion at High Sweat Rate
Kidney Nephron
Eccrine Gland
Ultrafiltration & Clearence
Selective electrolyte reabsorption
Excretion of metabolic byproducts
High sodium excretion
One Solution Spanning Multiple Care Settings
Seamless integration across all treatment environments
Emergency Admission
- Easy to deploy
- Rapid patient response
Inpatient Care
- High fluid volume removal
- Patient’s comfort
Outpatient Care
- Reduction in diuretic dosages
- Simple Transition Of Care (TOC)
Promising Safety and Effectiveness
Backed by Dual FDA Breakthrough Designations for
Heart Failure and End Stage Kidney Disease
Heart Failure and End Stage Kidney Disease
>1000ml
Volume of fluid removed
per 4 Hr treatment
per 4 Hr treatment
>40%
Reduction in
NT-ProBNP Levels
NT-ProBNP Levels
>50%
Reduction in diuretics
dosages
dosages
0%
Device or procedure
related adverse events
related adverse events
78%
Reduction in Intra Dialytic
Weight Gain (IDWG)
Weight Gain (IDWG)
900-1200ml
Volume of fluids removed
per 4.5 Hr treatment
per 4.5 Hr treatment
40%
Reduction in
ultrafiltration rates
ultrafiltration rates
0%
Device or procedure
related adverse events
related adverse events
Aronson et al. J. Card Fail 2025
Armaly et al. Renal Failure 2024
Leadership
Noam Josephy, MD MBA
Chief Executive Office
Yaacov Nitzan
Chief Technology Officer
Rotem Katzenellenbogen
Chief Product Officer
Stacey Bunk
Vice President, Market Access
Yael Lev Haber
Head of Corporate Affairs
Scientific Advisory Board
William Abraham, MD
Advanced Heart Failure and Transplant Cardiology
Ohio State University
Ohio State University
Dan Bensimhon, MD
Director, Advanced Heart Failure & Mechanical Circulatory Support,
Cone Health, Greensboro, NC
Cone Health, Greensboro, NC
Doron Aronson, MD
Director, Inpatient Cardiology Unit,
Rambam MC, Israel
Rambam MC, Israel
Ron Wald, MD
Director of Hemodialysis,
St. Michael’s Hospital, Toronto Canada
St. Michael’s Hospital, Toronto Canada
Jennifer E. Flythe, MD
Chief, UNC Division of Nephrology & Hypertension
UNC School of Medicine
UNC School of Medicine
Yoel Fink, PhD
Danae & Vasilis Salapatas
Professor in Materials Science & Engineering,
Massachusetts Institute of Technology
Professor in Materials Science & Engineering,
Massachusetts Institute of Technology
News
December 9, 2022
